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īefore the availability of vaccines, RV was the leading cause of severe gastroenteritis in children < 5 year of age worldwide. RV has also been found to be a major etiologic agent for pediatric nosocomial AGE. Rotavirus (RV) infection is a significant cause of hospitalization in children, and is associated with an important consumption of health care resources representing a significant clinical and economic burden for the health care system in developed countries.
#Cid episode 1235 registration#
Increasing VCR in areas with intermediate and low coverage rates would significantly reduce the severe burden of RVGE that requires hospital management in Spain.Ĭlinical trial registration Not applicable RVGE hospitalization ratios are highly dependent on the RV VCR. The likelihood of hospitalization due to RVGE was 56% (IC95%, 51–61%) and 27% (IC95%, 18–35%) lower in areas with high and intermediate VCR, respectively, compared to the low VCR areas. RVGE hospital admissions accounted for 2.82% (95 CI 2.72–3.00) and 43.84% (95% CI 40.53–47.21) of all-cause and Acute Gastroenteritis (AGE) hospitalizations in children under 5 years of age, respectively. Resultsįrom June 2013 to May 2018, data from 1731 RVGE hospitalizations (16.47% of which were nosocomial) were collected from the 12 study hospitals.
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The annual ratio of RVGE to the total number of all-cause hospitalizations in children 60%) VCR. All children admitted to the study hospitals with a RVGE confirmed diagnosis during a 5-year period were selected. Observational, multicenter, cross-sectional, medical record-based study. The aim of this study was to assess the ratio of RV gastroenteritis (RVGE) admissions to all-cause hospitalizations in children under 5 years of age in areas with different VCR. RV vaccination has reached an intermediate vaccination coverage rate (VCR) but with substantial differences between provinces. Rotavirus (RV) vaccines are available in Spain since 2006 but are not included in the National Immunization Program.